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Merck
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Documenti fondamentali

HPA004765

Sigma-Aldrich

Anti-NGFR antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sinonimo/i:

Anti-CD271 antigen antibody produced in rabbit, Anti-Gp80-LNGFR antibody produced in rabbit, Anti-Low affinity neurotrophin receptor p75NTR antibody produced in rabbit, Anti-Low-affinity nerve growth factor receptor antibody produced in rabbit, Anti-NGF receptor antibody produced in rabbit, Anti-Tumor necrosis factor receptor superfamily member 16 precursor antibody produced in rabbit, Anti-p75 ICD antibody produced in rabbit

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About This Item

Numero MDL:
MFCD00282384
Codice UNSPSC:
12352203
Numero Human Protein Atlas:
HPA004765
NACRES:
NA.43

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Nome Commerciale

Prestige Antibodies® Powered by Atlas Antibodies

Forma fisica

buffered aqueous glycerol solution

Reattività contro le specie

human

Convalida avanzata

orthogonal RNAseq
recombinant expression
Learn more about Antibody Enhanced Validation

tecniche

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

Sequenza immunogenica

NKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSES

N° accesso UniProt

P08138

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NGFR(4804)

Descrizione generale

NGFR (nerve growth factor receptor) is a cell surface transmembrane glycoprotein. It belongs to the low-affinity neurotrophin receptor and tumor necrosis factor receptor superfamily. It is expressed on the surface of glial fibrillary acidic protein δ (GFAPδ) cells of the human brain. In addition to the brain, it is also expressed in liver, lung, and muscle cells.

Immunogeno

Tumor necrosis factor receptor superfamily member 16 precursor recombinant protein epitope signature tag (PrEST)

Applicazioni

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Azioni biochim/fisiol

NGFR (nerve growth factor receptor) plays a crucial role in the neuronal survival, differentiation and development of neurons in adult brain. It has been reported that the membrane-spanning region and cytoplasmic domain of NGFR plays an essential role in signal transduction during neuronal differentiation. In CNS and peripheral tissues, NGFR acts as a clock gene and its activity is modulated by helix-loop-helix transcription factors: CLOCK and BMAL1.

Caratteristiche e vantaggi

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST70014

Stato fisico

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Note legali

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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D L Baker et al.
The American journal of pathology, 139(1), 115-122 (1991-07-01)
Nerve growth factor (NGF) is important to the survival, development, and differentiation of neurons. Its action is mediated by a specific cell surface transmembrane glycoprotein, nerve growth factor receptor (NGFR). In this study, NGFR expression by human fetal and adult
D Krahl et al.
The British journal of dermatology, 163(1), 138-145 (2010-02-27)
Tumour development is frequently described in the basic pathology literature as a recapitulation of embryogenesis. However, a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely overlooked. The low-affinity p75 neurotrophin receptor (p75NTR)
Miriam E van Strien et al.
Stem cells translational medicine, 3(4), 470-480 (2014-03-08)
Neural progenitor cells (NPCs) in the subventricular zone (SVZ) hold promise for future therapy for neurodegenerative disorders, because the stimulation of adult neurogenesis could potentially restore the function of degenerating neurons and glia. To obtain more knowledge on these NPCs
Ryan C Johnson et al.
American journal of clinical pathology, 142(6), 795-802 (2014-11-13)
We retrospectively tested the prognostic and diagnostic significance of CD271+ mesenchymal stromal cell (MSC) density in cytopenic patients who underwent bone marrow biopsy to evaluate for myelodysplastic syndromes (MDS). CD271+ MSC density was quantitated by automated image analysis of tissue
H Yan et al.
Science (New York, N.Y.), 252(5005), 561-563 (1991-04-26)
To determine the domains of the low-affinity nerve growth factor (NGF) receptor required for appropriate signal transduction, a series of hybrid receptors were constructed that consisted of the extracellular ligand-binding domain of the human epidermal growth factor (EGF) receptor (EGFR)
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