SRP3157
Sox2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥95% (HPLC)
≥95% (SDS-PAGE)
Stato
lyophilized
PM
34.3 kDa
Confezionamento
pkg of 25 μg
tecniche
cell culture | mammalian: suitable
Impurezze
<0.1 EU/μg endotoxin, tested
Colore
white
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... SOX2(6657)
Descrizione generale
Sox2 (sex determining region Y (SRY)-box 2) is one of the 20 human SOX transcription factors, which are characterized by the highly conserved ∼80-residues DNA-binding HMG (high-mobility group) domain. This domain was initially identified in the testis-determining factor Sry.
Recombinant human Sox2 is a 34.3 kDa protein containing 317 amino-acid residues.
Recombinant human Sox2 is a 34.3 kDa protein containing 317 amino-acid residues.
Azioni biochim/fisiol
Sox2 (sex determining region Y (SRY)-box 2) transcription factor participates in maintaining self-renewal and pluripotency of embryonic stem cells. The expression of this protein is aberrant in various human malignancies, and it acts as an oncogene in esophageal squamous cell carcinoma (SCC). SOX2 promotes proilferation, migration and adhesion abilities of dental pulp stem cells (DPSCs), and this might have applications in tissue engineering. It participates in Ewing′s sarcoma cell proliferation, and its inactivation results in apoptosis and G1/S arrest, in a PI3K (phosphoinositide 3-kinase)/Akt pathway-mediated manner.
Sequenza
MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM
Stato fisico
Lyophilized from 10 mM Sodium Acetate, pH 6.0.
Ricostituzione
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1- 1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
High sex determining region Y-box 2 (SOX2) expression correlates with absence of nodal metastasis in esophageal squamous cell carcinoma.
Chuang WY et al
International Journal of Clinical and Experimental Pathology, 8(8), 9248-9255 (2015)
Effects of SOX2 on Proliferation, Migration and Adhesion of Human Dental Pulp Stem Cells.
Liu P et al
PLoS ONE, 10(10), e0141346-e0141346 (2015)
Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway.
Ren C et al
Journal of Experimental & Clinical Cancer Research, 35, 44-44 (2016)
The crystal structure of the Sox4 HMG domain-DNA complex suggests a mechanism for positional interdependence in DNA recognition.
Jauch R et al
The Biochemical Journal, 443(1), 39-47 (2012)
Samudyata et al.
Experimental cell research, 381(1), 129-138 (2019-05-12)
Sox2 is a master transcriptional regulator of embryonic development. In this study, we determined the protein interactome of Sox2 in the chromatin and nucleoplasm of mouse embryonic stem (mES) cells. Apart from canonical interactions with pluripotency-regulating transcription factors, we identified
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