SML3833

NB-598

≥98% (HPLC)

• Sinonimo/i: (E)-3-[(3,3′-Bithiophen)-5-ylmethoxy]-N-(6,6-dimethyl-2-hepten-4-ynyl)- N-ethylbenzylamine, 3-([3,3′-Bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethylbenzenemethanamine, NB 598
• Formula empirica (notazione di Hill): C₂₇H₃₁NOS₂
• Numero CAS: 131060-14-5
• Peso molecolare: 449.67
• Numero MDL: MFCD00898838
• Codice UNSPSC: 51111800
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear (Warmed)
• Temperatura di conservazione: -10 to -25°C
• Stringa SMILE: [s]1c(cc(c1)c3c[s]cc3)COc2cc(ccc2)CN(CC)C\C=C\C#CC(C)(C)C
• InChI: 1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+; KIRGLCXNEVICOG-SOFGYWHQSA-N

Descrizione

Azioni biochim/fisiol

NB-598 is a potent and specific inhibitor of mammalian squalene epoxidase (SQLE) that suppresses triglyceride biosynthesis through the farnesol pathway. It decreases cholesterol levels in cells. NB-598 exhibit potent cytotoxic effects in subset of f neuroendocrine tumors, such as small cell lung cancers through accumulation of toxic squalene with in sensitive cancer cells.

Potent and specific inhibitor of mammalian squalene epoxidase (SQLE) that suppresses triglyceride biosynthesis through the farnesol pathway

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable