SML3223

CAY10566

≥98% (HPLC)

• Sinonimo/i: 2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole, Abbott compound 74, Abbott-28c, CAY 10566, CAY-10566, SCD1 inhibitor 28c
• Formula empirica (notazione di Hill): C₁₈H₁₇ClFN₅O₂
• Numero CAS: 944808-88-2
• Peso molecolare: 389.81
• Numero MDL: MFCD11976899
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: off-white to orange
• Solubilità: DMSO: 2 mg/mL, clear (warmed)
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3; WFOFPVXMPTVOTJ-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

CAY10566 is a potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 26 nM/hSCD1 and 4.5 nM/mSCD1; IC50 >10 μM/75 receptors, transporters, ion channels). CAY10566 effectively blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50 = 7.9 nM by C17:1/C17:0 ratio; IC50 = 6.8 nM by C16:1/C16:0 ratio) and exhibits good metabolic stability (by rat & mouse liver microsome assays) and oral availability (rat F = 59.2%; 5 mg/kg p.o.). CAY10566 is typically used in the range from 0.1-10 μM for cell treatment.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable