SML0120
Perhexiline maleate salt
≥98% (HPLC)
Sinonimo/i:
2-(2,2-Dicyclohexylethyl)piperidine
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About This Item
Formula empirica (notazione di Hill):
C19H35N · C4H4O4
Numero CAS:
Peso molecolare:
393.56
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.25
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Colore
white to tan
Solubilità
DMSO: ≥5 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
InChI
1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
JDZOTSLZMQDFLG-BTJKTKAUSA-N
Informazioni sul gene
human ... CPT1B(1375) , CPT2(1376) , MTOR(2475)
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Descrizione generale
Perhexiline maleate regulates coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with papilledema and proximal myopathy.
Applicazioni
Perhexiline maleate salt has been used as a stock for worm lifespan assay. It has also been used to block fatty acid oxidation.
Perhexiline maleate salt has been used to block fatty acid oxidation. It has also been used as 5′ adenosine monophosphate-activated protein kinase (AMPK) activator and in worm lifespan assay.
Azioni biochim/fisiol
Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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