SML3210

Sotrastaurin

≥98% (HPLC)

• Sinonimo/i: 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione, 3-(1H-Indol-3-yl)-4-[2-(4-methyl-piperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione, AEB 071, AEB-071, AEB071, NVP-AEB071, Sotrastaurin
• Formula empirica (notazione di Hill): C₂₅H₂₂N₆O₂
• Numero CAS: 425637-18-9
• Peso molecolare: 438.48
• Numero MDL: MFCD16038049
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: faint brown to dark red
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5C=CC=CC5=NC(N6CCN(CC6)C)=N4
• InChI: 1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33); OAVGBZOFDPFGPJ-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor with in vivo immunosuppressive efficacy.

Sotrastaurin (AEB071) is an orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor (Ki in nM/isoform = 0.95/α, 0.64/βI, 2.1/δ, 3.2/ε, 1.8/η and 2.2/θ; IC50 = 2.1/α, 2.0/βI, 1.3/δ, 6.2/ε, 6.1/η and 1.0/θ with 10 μM ATP). Sotrastaurin inhibits TCR/CD28-mediated T cell activation in cultures (IC50 = 54 nM by Jurkat IL-2 promoter reporter line) and exhibits in vivo immunosuppressive efficacy in rat models of local graft versus host (GvH) reaction and cardiac transplantation (10 and 30 mg/kg p.o. q.d. or b.i.d.).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable