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SML2313

Sigma-Aldrich

Higenamine hydrochloride

≥95% (HPLC)

Sinonimo/i:

Higenamine hydrochloride, (RS)-Norcoclaurine hydrochloride, (±)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-Isoquinolinediol hydrochloride, (±)-Demethylcoclaurine, (±)-Norcoclaurine hydrochloride, (±)-O-Demethylcoclaurine hydrochloride, 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquinolinediol hydrochloride, dl-Demethylcoclaurine hydrochloride, (±)-Demethylcoclaurine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C16H17NO3 · HCl
Numero CAS:
11041-94-4
Peso molecolare:
307.77
Numero MDL:
MFCD01717353
Codice UNSPSC:
12352116
NACRES:
NA.77

Saggio

≥95% (HPLC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: 2 mg/mL, clear (warmed)

Temperatura di conservazione

2-8°C

Stringa SMILE

OC1=C(O)C=C(C(CC2=CC=C(O)C=C2)NCC3)C3=C1.Cl

InChI

1S/C16H17NO3.ClH/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14;/h1-4,8-9,14,17-20H,5-7H2;1H
SWWQQSDRUYSMAR-UHFFFAOYSA-N

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Azioni biochim/fisiol

Higenamine is an anti-inflammatory agent that protects cells from oxidant injury. Higenamine is a pharmacological modulator of heme oxygenase 1(HO-1). It also displays agonist activity at adrenergic β2 receptor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Wenjiang Duan et al.
Experimental and therapeutic medicine, 12(5), 3107-3112 (2016-11-25)
Existing in Ranunculaceae Aconitum and tomato, with the chemical name 1-phydroxybenzyl-1,2,3,4-tetrahy-droisoquinoline, higenamine is widely distributed in China. Higenamine's anti-inflammatory, antioxidant and anti-apoptotic effects have been identified in previous studies. The present study attempted to determine the protective effect of higenamine
Eisuke Kato et al.
Bioorganic & medicinal chemistry, 25(24), 6412-6416 (2017-10-27)
β2-Adrenergic receptor (β2AR) agonists are employed as bronchodilators to treat pulmonary disorders, but are attracting attention for their modulation of glucose handling and energy expenditure. Higenamine is a tetrahydroisoquinoline present in several plant species and has β2AR agonist activity, but
Xiaoxia An et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 1710-1717 (2017-09-30)
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). The numerous clinical symptoms of DGP and the great cost on the treatment of DGP seriously lowered the patients' life quality. However, the pathogenic mechanism of DGP is still

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