SML1637

Hexaminolevulinate hydrochloride

≥98% (HPLC)

• Sinonimo/i: 5-Aminolevulinic acid hexyl ester HAL hydrochloride, 5-Aminolevulinic acid hexyl ester hydrochloride, HAL, Hexvix, Hexyl 5-aminolevulinate hydrochloride, P 1206, n-Hexyl 5-aminolevulinate hydrochloride
• Formula empirica (notazione di Hill): C₁₁H₂₁NO₃ · HCl
• Numero CAS: 140898-91-5
• Peso molecolare: 251.75
• Numero MDL: MFCD03695491
• Codice UNSPSC: 12352200
• ID PubChem: 329825978
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: H₂O: 20 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: CCCCCCOC(CCC(CN)=O)=O.[H]Cl
• InChI: 1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H; LZYXPFZBAZTOCH-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.

Hexaminolevulinate is a hexyl ester of 5-Aminolevulinic acid; imaging agen for fluorescence cyctoscopy; photosensitizer.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3