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SML1608

Sigma-Aldrich

Besifloxacin hydrochloride

≥98% (HPLC)

Sinonimo/i:

7-[-3-Aminoazepam-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C19H21ClFN3O3 · HCl
Numero CAS:
1398566-43-2
Peso molecolare:
430.30
Numero MDL:
MFCD23712955
Codice UNSPSC:
12352200
ID PubChem:
329825494
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to light brown

Solubilità

DMSO: 2 mg/mL, clear (warmed)

Temperatura di conservazione

−20°C

Stringa SMILE

[H]Cl.OC(C1=CN(C2CC2)C3=C(Cl)C(N4CCCCC(N)C4)=C(F)C=C3C1=O)=O

Azioni biochim/fisiol

Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic.
Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic. Besifloxacin is effective against gram positive and negative, aerobic and anerobic bacteria. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Besifloxacin inhibits both DNA gyrase and topoisomerase IV at nearly equal concentrations. It is used clinically primarily in the treatment of bacterial conjunctivitis.
Besifloxacin stops the production of pro-inflammatory cytokines in vitro.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Jean Deschênes et al.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 50(3), 184-191 (2015-06-05)
Acute bacterial conjunctivitis is a common infection of the ocular surface. Increasing rates of bacterial resistance have prompted the development of new antibiotics with improved activity against the bacterial species most often found in this disease. Besifloxacin is the first
Synthetic approaches to the 2009 new drugs
Liu K K C, et al.
Bioorganic & Medicinal Chemistry, 19(3), 1136-1154 (2011)
Alexander T Nguyen et al.
Cornea, 34(8), 967-971 (2015-06-16)
To present the clinical outcome of 3 cases of ocular surface infections by Mycobacterium chelonae treated with besifloxacin (0.6%, Besivance; Bausch & Lomb, Tampa, FL). In this retrospective review of a small case series, we reviewed the medical records of
Timothy L Comstock et al.
Clinical ophthalmology (Auckland, N.Z.), 4, 215-225 (2010-05-14)
Bacterial conjunctivitis, commonly known as pink eye, is demographically unbiased in its prevalence and can be caused by a variety of aerobic and anaerobic bacteria. Timely empiric treatment with a broad-spectrum anti-infective, such as a topical fluoroquinolone, is critical in

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