SML0959

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene

≥98% (HPLC)

• Sinonimo/i: Compound 16, N,N′-(Naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)
• Formula empirica (notazione di Hill): C₂₄H₂₂N₂O₆S₂
• Numero CAS: 321694-20-6
• Peso molecolare: 498.57
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: , white to light yellow to light gray
• Solubilità: DMSO: 20 mg/mL, clear
• Temperatura di conservazione: 2-8°C

Descrizione

Azioni biochim/fisiol

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene is a non-covalent inhibitor of the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). The Keap1–Nrf2 protein–protein interaction is considered a critical point of the Keap1–Nrf2–ARE (antioxidant response elements) system that protects cells from oxidative stress. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene prevents Keap1 repression of Nrf2 activation, allowing Nrf2 to initiate antioxidant response element (ARE) to protect the cell. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene has an IC₅₀ of 2.7 micromolar and specifically binds to the Keap1 Kelch-DC domain.

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable