SML0693

LY-333531 hydrochloride

≥98% (HPLC)

• Sinonimo/i: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride, Ruboxistaurin
• Formula empirica (notazione di Hill): C₂₈H₂₈N₄O₃ · HCl
• Numero CAS: 169939-93-9
• Peso molecolare: 505.01
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated; protect from light
• Colore: orange-red
• Solubilità: DMSO: 10 mg/mL, clear
• Temperatura di conservazione: −20°C
• InChI: 1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1; NYQIEYDJYFVLPO-FERBBOLQSA-N

Descrizione

Descrizione generale

LY-333531 hydrochloride is also known as ruboxistaurin.

Applicazioni

LY-333531 hydrochloride/ruboxistaurin has been used as a PKCB blocker to compare phosphopeptides derived from stimulated wild-type cells to phosphopeptides derived from either PKCB knockout cells or wild-type cells.

Azioni biochim/fisiol

LY333531 is a potent inhibitor of protein kinase Cβ (PKCβ; 4.7 and 5.9 nM IC₅₀ values for PKCβ1 and PKCβ2, respectively). PKCβ isoforms are overexpressed in states of oxidative stress, especially in association with diabetes. In diabetic rats, LY333531 improves blood flow and leukocyte entrapment in the retina, and protects against myocardial hypertrophy and cardiac dysfunction.

Caratteristiche e vantaggi

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Altre note

Light sensitive

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable