SML0488

Dobesilate Calcium

≥98% (HPLC)

• Sinonimo/i: 2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate
• Formula empirica (notazione di Hill): C₆H₅O₅S · 0.5Ca
• Numero CAS: 20123-80-2
• Peso molecolare: 209.20
• Numero MDL: MFCD00867249
• Codice UNSPSC: 12352200
• ID PubChem: 329825438
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: H₂O: 15 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: [Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O
• InChI: 1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2; QGNBTYAQAPLTMX-UHFFFAOYSA-L

Descrizione

Descrizione generale

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Applicazioni

Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.

Azioni biochim/fisiol

Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.

Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.

Caratteristiche e vantaggi

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315 - H319 - H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable