SML0091

L-Dopa ethyl ester

≥98% (HPLC)

• Sinonimo/i: 3,4-Dihydroxy-L-phenylalanine ethyl ester, 3-Hydroxy-L-tyrosine ethyl ester, Etilevodopa, L-Dopa ethyl ester, L-Dopa-Et, Levodopa ethyl ester, O-Ethyl-DOPA, TV-1203
• Formula empirica (notazione di Hill): C₁₁H₁₅NO₄
• Numero CAS: 37178-37-3
• Peso molecolare: 225.24
• Numero MDL: MFCD00871210
• Codice UNSPSC: 12352108
• ID PubChem: 329825151
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Attività ottica: [α]/D +15 to +19°, c = 1 in methanol ([α]/D)
• Colore: white to tan
• Solubilità: H₂O: ≥12 mg/mL at warmed to 60 °C
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
• InChI: 1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1; NULMGOSOSZBEQL-QMMMGPOBSA-N
• Informazioni sul gene: human ... DRD3(1814)

Descrizione

Applicazioni

L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).

Azioni biochim/fisiol

L-Dopa ethyl ester (L-Dopa) is a dopamine replacement drug. It is used as a potent therapeutic for Parkinson disease (PD). L-Dopa has some long-term side effects, such as the deterioration of motor function.

L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.

Caratteristiche e vantaggi

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable