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SMB01008

Sigma-Aldrich

Aschantin

≥90% (LC/MS-ELSD)

Sinonimo/i:

(+)-Aschantin, 5-[(3S,3aR,6S,6aR)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole

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About This Item

Formula empirica (notazione di Hill):
C22H24O7
Numero CAS:
13060-15-6
Peso molecolare:
400.42
Codice UNSPSC:
12352205

Saggio

≥90% (LC/MS-ELSD)

Forma fisica

solid

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Temperatura di conservazione

−20°C

InChI

1S/C22H24O7/c1-23-18-7-13(8-19(24-2)22(18)25-3)21-15-10-26-20(14(15)9-27-21)12-4-5-16-17(6-12)29-11-28-16/h4-8,14-15,20-21H,9-11H2,1-3H3/t14-,15-,20+,21+/m0/s1
ONDWGDNAFRAXCN-VUEDXXQZSA-N

Categorie correlate

Descrizione generale

Aschantin, a bioactive lignan, is a natural product commonly available from Magnolia Sp, and Artemisia Sp. plants. This secondary metabolite derived from plant sources exhibits various biological activities such as anti-inflammatory, antioxidant, and anticancer activities.

Applicazioni

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Azioni biochim/fisiol

Aschantin has various biological activities including peroxynitrite scavenging capacity, inhibition of inducible NO synthetase, antiplasmodial activity, Ca2+-antagonistic activity, platelet activating factor-antagonistic activity, and chemo-preventative or therapeutic activity mediated via inhibition of mTOR kinase.
The anticancer activity of aschantin is achieved by inhibiting Akt, a protein that plays a crucial role in promoting cancer cell growth and proliferation. By blocking Akt, aschantin disrupts multiple signaling pathways that are essential for cancer cells to thrive and multiply. This disruption ultimately leads to the suppression of cancer cell proliferation, making it an effective strategy for combating cancer.

Caratteristiche e vantaggi

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

Altre note

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Soon-Sang Kwon et al.
Molecules (Basel, Switzerland), 21(5) (2016-04-30)
Aschantin is a bioactive neolignan found in Magnolia flos with antiplasmodial, Ca(2+)-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. We investigated its inhibitory effects on the activities of eight major human cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes of human

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