SMB00912
Pseudouridine
≥98% (HPLC)
Sinonimo/i:
Pseudouridine, β-Pseudouridine, ψ-Uridine, 5-(β-D-Ribofuranosyl)uracil
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About This Item
Formula empirica (notazione di Hill):
C9H12N2O6
Numero CAS:
Peso molecolare:
244.20
Codice UNSPSC:
41106305
NACRES:
NA.79
Prodotti consigliati
Origine biologica
synthetic (chemical)
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
PM
244.2
Colore
white to off-white
Punto di fusione
222 °C ((432 °F ))
Solubilità
water: soluble
Temperatura di conservazione
2-8°C
InChI
1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
PTJWIQPHWPFNBW-GBNDHIKLSA-N
Descrizione generale
Pseudouridine (Ψ) stands as an isomer of the nucleoside uridine, featuring a carbon-carbon bond instead of the typical nitrogen-carbon glycosidic bond connecting uracil. It represents the most prevalent among the myriad modified nucleosides within RNA, with a presence spanning various species and RNA classes. The enzymatic action of Ψ synthases induces post-transcriptional isomerization of specific uridine residues, a process known as pseudouridylation. This modification, particularly in rRNA and tRNA, plays a vital role in fine-tuning and stabilizing regional structures, contributing to mRNA decoding, ribosome assembly, processing, and translation functions. Moreover, β-pseudouridine, identified in tRNAs across bacteria, archaea, and eukaryotes, has demonstrated potential in reducing radiation-induced chromosome aberrations in human lymphocytes. Its utility as a cancer and proliferation biomarker positions it as a valuable asset in metabolomics and biochemical research.
Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a β-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite. Pseudouridine is found in all species and in all classes of RNA except mRNA. It is formed by enzymes called pseudouridine synthases, which post-transcriptionally isomerize specific uridine residues in RNA.
Applicazioni
Pseudouridine is a versatile compound and a biomarker that finds application in metabolomics and biochemical research.
Caratteristiche e vantaggi
- High-purity compound suitable for a wide variety of research applications
Altre note
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Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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