SBR00037

Solithromycin

≥98% (HPLC)

• Sinonimo/i: 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, CEM-101, OP-1068
• Formula empirica (notazione di Hill): C₄₃H₆₅FN₆O₁₀
• Peso molecolare: 845.01
• Numero MDL: MFCD30207880
• Codice UNSPSC: 51102829
• NACRES: NA.76

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to off-white
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: −20°C
• InChI: 1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1; IXXFZUPTQVDPPK-ZAWHAJPISA-N

Descrizione

Descrizione generale

Solithromycin is a highly potent next-generation macrolid. the first fluoroketolid. which has potent activity against most macrolide-resistant strains. Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness.

Applicazioni

Solithromycin has been shown to have potentent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRS. enterococc according to in vitro and in vivo research. Solithromycin has been used in:

• the research on the anti-inflammatory effects of macrolides
• the research of potency of solithromycin in comparison to other antimicrobials
• in ithe research of the vitro activity of solithromycin against clinical N. gonorrhoeae isolates and reference strain

Azioni biochim/fisiol

Mode of Action: Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolide. it should impair bacterial ribosomal subunit formation.

Antimicrobial spectrum: Active against bacteria like Legionella, Chlamydophila, Chlamydia, Mycoplasma, and Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections

Caratteristiche e vantaggi

High quality antibiotic suitable for mulitple research applications

Altre note

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable