SAB5700569

Anti-Phospho-ABL1-Y412 antibody produced in rabbit

• Sinonimo/i: ABL, ABL1, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, c-Abl, p150, v-abl
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: 123
• Reattività contro le specie: rat, mouse, human
• Concentrazione: 0.51mg/ml
• tecniche: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• N° accesso UniProt: P00519
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pTyr412)
• Informazioni sul gene: human ... ABL1 (25)

Descrizione

Descrizione generale

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Immunogeno

A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1.

Stato fisico

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stoccaggio e stabilità

Store at -20℃. Avoid freeze / thaw cycles.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable