SAB5700387

Anti-Phospho-p38 MAPK-T180/Y182 antibody produced in rabbit

• Sinonimo/i: CSBP, CSBP1, CSBP2, CSPB1, EXIP, MAPK14, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38 MAPK, p38ALPHA
• Codice UNSPSC: 12352203
• NACRES: NA.43

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: 29; 34; 35; 41
• Reattività contro le specie: mouse, human, rat
• Concentrazione: 5.56 mg/ml
• tecniche: immunofluorescence: 1:50-1:200; western blot: 1:500-1:2000
• N° accesso UniProt: Q16539
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pThr180/pTyr182)
• Informazioni sul gene: human ... MAPK14(1432)

Descrizione

Descrizione generale

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Immunogeno

A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK (NP_620581.1).

Stato fisico

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stoccaggio e stabilità

Store at -20℃. Avoid freeze / thaw cycles.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable