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Documenti fondamentali

SAB4503289

Sigma-Aldrich

Anti-GPR101 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

GPR101, Probable G-protein coupled receptor 101

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 56 kDa

Reattività contro le specie

human, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GPR101(83550)

Descrizione generale

Anti-GPR101 Antibody detects endogenous levels of total GPR101 protein.
G protein-coupled receptor 101 (GPR101) codes for an an orphan G protein-coupled receptor. It is expressed at high level in the hypothalamus. The GPR101 gene is mapped to human chromosome Xq26.3.

Immunogeno

The antiserum was produced against synthesized peptide derived from human GPR101.

Immunogen Range: 451-500

Azioni biochim/fisiol

Mutation in G protein-coupled receptor 101 (GPR101) gene result in acromegaly. The GPR101 protein is expected to play an important role in hypothalamic control of energy homeostasis. Duplication of the GPR101 gene leads to X-linked acrogigantism (XLAG).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Gigantism: X-linked acrogigantism and GPR101 mutations.
Iacovazzo D and Korbonits M
Growth Hormone & IGF Research, 30-31, 64-69 (2016)
Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study.
Iacovazzo D, et al.
Acta Neuropathologica Communications, 4(1), 56-56 (2016)
Giampaolo Trivellin et al.
Endocrine-related cancer, 23(5), 357-365 (2016-03-11)
Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage
Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas.
Lecoq AL, et al.
European Journal of Endocrinology, 174(4), 523-530 (2016)
Giampaolo Trivellin et al.
Journal of molecular endocrinology, 57(2), 97-111 (2016-06-11)
We recently showed that Xq26.3 microduplications cause X-linked acrogigantism (X-LAG). X-LAG patients mainly present with growth hormone and prolactin-secreting adenomas and share a minimal duplicated region containing at least four genes. GPR101 was the only gene highly expressed in their

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