SAB4502973
Anti-TIMP3 antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3
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About This Item
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
antigen 24 kDa
Reattività contro le specie
mouse, rat, human
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:10000
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TIMP3(7078)
Descrizione generale
Tissue inhibitor of metalloproteinases 3 (TIMP3) belongs to the matrix metalloproteinases inhibitor family. TIMP3 gene is mapped to human chromosome 22q12.3. TIMP3 possesses a C-terminal N-linked glycosylation site at asparagine residue. This protein comprises 12 conserved cysteine residues stabilized by six disulfide bonds in its secondary structure. TIMP-3 gene expression is higher in murine lung and kidney.
Immunogeno
The antiserum was produced against synthesized peptide derived from human TIMP3.
Immunogen Range: 91-140
Immunogen Range: 91-140
Azioni biochim/fisiol
Tissue inhibitor of metalloproteinases 3 (TIMP3) inhibits membrane-type matrix metalloproteinases (MT-MMPs) and the tumor necrosis factor α–converting enzyme (TACE). It displays a high affinity for the proteoglycans associated with extracellular matrix (ECM) and displays tight binding with sulfated glycosaminoglycans. Mutations in the TIMP-3 gene is implicated in Sorsby′s fundus dystrophy which is characterized by choroidal neovascularization, vision loss, and abnormal Bruch′s membrane thickening. Downregulation of TIMP3 gene due to allelic losses on 22q12 chromosomal location is correlated to meningiomas. TIMP3 participates in cardiac remodeling. Low levels of TIMP3 protein are observed in scenarios of ischemic and dilated cardiomyopathy. This protein elicits proapoptotic activity and is an inhibitor of angiogenesis and tumor growth.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Dimitri Barski et al.
Brain pathology (Zurich, Switzerland), 20(3), 623-631 (2009-11-20)
The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types of cancers, with controversial findings in meningiomas. We performed direct sodium bisulfite sequencing in a series
Anne M Macgregor et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 57(3), 207-213 (2008-10-29)
Tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) is an important regulator of matrix metalloproteinase activity in many types of disease, including atherosclerosis, neoplasia, and inflammatory conditions. Among TIMPs, TIMP-3 uniquely binds the extracellular matrix (ECM). We performed IHC staining on 17
Likun Yang et al.
Molecular medicine reports, 23(5) (2021-03-25)
Mycoplasma pneumoniae pneumonia (MPP) is a type of pneumonia induced by M. pneumoniae (MP) infection. The present study investigated the effect of long non‑coding RNA growth arrest‑specific 5 (GAS5) in MPP and the underlying molecular mechanism of this. The expression of GAS5
Jingjing Zhang et al.
Molecular and cellular biochemistry, 398(1-2), 123-134 (2014-09-10)
Retinal pigment epithelium (RPE) exerts critical roles in the maintenance of the normal functions of the retina, whereas RPE dysfunction can induce retina neovascularization. p75 neurotrophin receptor (p75(NTR)) has been shown to play essential roles in angiogenesis. However, the function
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