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Documenti fondamentali

SAB4502804

Sigma-Aldrich

Anti-GLUT3, C-Terminal antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

GLUT-3, GLUT3, Glucose transporter type 3 brain, SLC2A3, Solute carrier family 2 facilitated glucose transporter member 3

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 53 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SLC2A3(6515)

Descrizione generale

Anti-GLUT3 Antibody detects endogenous levels of total GLUT3 protein.

Solute carrier family 2 member 3 (SLC2A3), also known as glucose transporter -3 (GLUT-3), is encoded by the gene mapped to human chromosome 12p13.3. The encoded protein belongs to the SLC2 family of GLUTs.

Immunogeno

The antiserum was produced against synthesized peptide derived from human GLUT3.

Immunogen Range: 447-496

Applicazioni

Anti-GLUT3, C-Terminal antibody produced in rabbit has been used in immunocytochemistry.

Azioni biochim/fisiol

Solute carrier family 2 member 3 (SLC2A3)/ glucose transporter -3 (GLUT-3) along with GLUT1, facilitates the transport of dehydroascorbic acid (DHA). It also plays a vital role in cerebral glucose metabolism, providing energy for the activity of neurons, which, in turn, moderates the excitatory-inhibitory balance impacting both brain development and activity-dependent neural plasticity. SLC2A3 is essential for or optimal preimplantation embryo development and survival. Mutation in the gene increases the risk of susceptibility to attention-deficit/hyperactivity disorder (ADHD).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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The facilitative glucose transporter GLUT3: 20 years of distinction.
Simpson I A, et al.
American Journal of Physiology. Endocrinology and Metabolism, 295(2), E242-E253 (2008)
Xiaogang Wu et al.
Neurosurgical review, 44(1), 411-422 (2020-01-04)
Hypoxia preconditioning (HPC), a well-established preconditioning model, has been shown to protect the brain against severe hypoxia or ischemia caused by traumatic brain injury (TBI), but the mechanism has not been well elucidated. Anaerobic glycolysis is the major way for
slc2a3 single?nucleotide polymorphism and duplication influence cognitive processing and population?specific risk for attention?deficit/hyperactivity disorder.
Merker S, et al.
Journal of Child Psychology and Psychiatry, and Allied Disciplines, 58(7), 798-809 (2017)
Energy requirements of odor transduction in the chemosensory cilia of olfactory sensory neurons rely on oxidative phosphorylation and glycolytic processing of extracellular glucose.
Villar P S, et al.
The Journal of Neuroscience, 37(23), 5736-5743 (2017)
The human Hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications.
Larhammar D, et al.
Genome Research, 12(12), 1910-1920 (2002)

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