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Key Documents

SAB4200678

Sigma-Aldrich

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

Sinonimo/i:

Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I

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About This Item

Codice UNSPSC:
51111800
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

COL-1, monoclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

pig, rat, human, deer, bovine

Concentrazione

~1 mg/mL

tecniche

ELISA: suitable
dot blot: suitable
immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum
immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue

Isotipo

IgG1

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... COL1A1(1277)

Descrizione generale

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.
Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogeno

bovine skin collagen type I

Applicazioni

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Azioni biochim/fisiol

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.
Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Stato fisico

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Endothelial cell-pericyte interactions stimulate basement membrane matrix assembly: Influence on vascular tube remodeling, maturation and stabilization
Blood, 114, 5091-101 (2009)
Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma.
Simon M-P, et al.
Nature Genetics, 15(10), 95-95 (1997)
Werkmeister JA., and Ramshaw JA
Acta Dermato-Venereologica. Supplementum, 69, 399-402 (1989)
Hu Z., et al.
Journal of Biomedical Materials Research Part A, 95, 1048-1054 null
Paeoniflorin prevents postoperative peritoneal adhesion formation in an experimental rat model.
Gao Q, et al.
Oncotarget, 8(55), 93899-93899 (2017)

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