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S9944

Sigma-Aldrich

Sibutramine

≥98% (HPLC), solid

Sinonimo/i:

1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine, Meridia, Reductil

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About This Item

Formula empirica (notazione di Hill):
C17H26ClN · HCl
Numero CAS:
84485-00-7
Peso molecolare:
316.31
Numero MDL:
MFCD04039806
Codice UNSPSC:
12352116
ID PubChem:
329824638
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Controllo stupefacenti

USDEA Schedule IV

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

DMSO: >30 mg/mL
H2O: insoluble

Ideatore

Abbott

Temperatura di conservazione

room temp

Stringa SMILE

O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

InChI

1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2
KFNNPQDSPLWLCX-UHFFFAOYSA-N

Informazioni sul gene

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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Applicazioni

Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.1

Azioni biochim/fisiol

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Caratteristiche e vantaggi

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Jamie D Dunn et al.
Journal of pharmaceutical and biomedical analysis, 54(3), 469-474 (2010-10-14)
In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput
Cibele S Borges et al.
PloS one, 8(6), e66091-e66091 (2013-06-19)
Sperm acquire motility and fertility capacity during epididymal transit, under the control of androgens and sympathetic innervations. It is already known that the acceleration of epididymal sperm transit time can lead to lower sperm quality. In a previous work we
Hiroaki Yashiro et al.
PloS one, 11(11), e0166198-e0166198 (2016-11-11)
Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA). Thus, D5D inhibition increases DGLA (precursor to anti-inflammatory
Alexandre V Ivachtchenko et al.
Journal of Alzheimer's disease : JAD, 58(4), 1043-1063 (2017-05-28)
Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and
Cristiani F Bortolatto et al.
Psychopharmacology, 232(13), 2239-2249 (2015-01-08)
The searching for safe and effective antiobesity drugs has been the subject of intense research. Previous studies have shown several pharmacological applications of organoselenium compounds; however, their possible anorectic-like actions have not been investigated. This study aims to investigate the
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