S7817

Scriptaid

≥95%, solid

• Sinonimo/i: 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide
• Formula empirica (notazione di Hill): C₁₈H₁₈N₂O₄
• Numero CAS: 287383-59-9
• Peso molecolare: 326.35
• Numero MDL: MFCD00386477
• Codice UNSPSC: 12352203
• ID PubChem: 329824590
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: solid
• Punto di fusione: 160-161 °C
• Solubilità: DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow; DMSO: 1 mg/mL; methanol: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23
• InChI: 1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21); JTDYUFSDZATMKU-UHFFFAOYSA-N

Descrizione

Descrizione generale

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Applicazioni

Scriptaid has been used in post activation of oocytes and embryo culture.

Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.^5,6

Azioni biochim/fisiol

Histone deacetylase inhibitor with lower toxicity than trichostatin A.

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.² Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.³ It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.⁴

Caratteristiche e vantaggi

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Note legali

Sold under license of U.S. Patent No. 6,544,957.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)