S4568

SCH 58261

≥98% (HPLC), solid

• Sinonimo/i: 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• Formula empirica (notazione di Hill): C₁₈H₁₅N₇O
• Numero CAS: 160098-96-4
• Peso molecolare: 345.36
• Numero MDL: MFCD00933778
• Codice UNSPSC: 12352200
• ID PubChem: 329824547
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Colore: off-white
• Solubilità: DMSO: soluble >10 mg/mL; H₂O: insoluble
• Stringa SMILE: Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5
• InChI: 1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22); UTLPKQYUXOEJIL-UHFFFAOYSA-N

Descrizione

Applicazioni

SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.⁴

Azioni biochim/fisiol

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

A_2A adenosine receptor antagonist.

Caratteristiche e vantaggi

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)