S193

Anti-Synapsin I antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Sinonimo/i: Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI
• Numero MDL: MFCD00282157
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: lyophilized powder
• PM: antigen ~80 kDa (Synapsin Ia)
• Reattività contro le specie: rat, mouse, human, bovine
• tecniche: dot blot: 1:1000; immunohistochemistry (frozen sections): 1:2000; immunoprecipitation (IP): 1 μg; indirect immunofluorescence: 1:2000; western blot: 1:1000
• N° accesso UniProt: P17600
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SYN1(6853) ; mouse ... Syn1(20964) ; rat ... Syn1(24949)

Descrizione

Descrizione generale

Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.

Immunogeno

synapsin I from bovine brain.

Applicazioni

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.

• Western Blotting (1 paper)
• immunohistochemistry
• immunoblotting
• immunoprecipitation
• ELISA.

Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.

Azioni biochim/fisiol

Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.

Stato fisico

Lyophilized from ammonium bicarbonate (5 mM)

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)