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P8511

Sigma-Aldrich

trans-2-Phenylcyclopropylamine hydrochloride

Sinonimo/i:

Tranylcypromine

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About This Item

Formula condensata:
C6H5C3H4NH2·HCl
Numero CAS:
1986-47-6
Peso molecolare:
169.65
Numero MDL:
MFCD00063602
Codice UNSPSC:
12352116
ID PubChem:
24278187
NACRES:
NA.77

Origine biologica

synthetic (organic)

Saggio

≥97% (TLC)

Stato

powder

Punto di fusione

162-169 °C (lit.)

Solubilità

ethanol: 50 mg/mL, clear to slightly hazy

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.N[C@@H]1C[C@H]1c2ccccc2

InChI

1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
ZPEFMSTTZXJOTM-OULXEKPRSA-N

Informazioni sul gene

human ... MAOA(4128) , MAOB(4129)

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Azioni biochim/fisiol

Non-selective MAO-A/B inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number
MKBW0574V
MKBR4169V
SLBC3356V
SLBC3356
081M1298

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Journal of cancer metastasis and treatment, 7 (2021-11-02)
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Jesse H Arbuckle et al.
mBio, 5(1), e01027-e01013 (2014-01-16)
Upon infection, the genome of herpes simplex virus is rapidly incorporated into nucleosomes displaying histone modifications characteristic of heterochromatic structures. The initiation of infection requires complex viral-cellular interactions that ultimately circumvent this repression by utilizing host cell enzymes to remove
Martin Engel et al.
Journal of neurochemistry, 149(4), 535-550 (2018-12-29)
Targeting epigenetic mechanisms has shown promise against several cancers but has so far been unsuccessful against glioblastoma (GBM). Altered histone 3 lysine 4 methylation and increased lysine-specific histone demethylase 1A (LSD1) expression in GBM tumours nonetheless suggest that epigenetic mechanisms
Kaisa A Salminen et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(12), 1891-1904 (2015-09-25)
The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug
M Angeles Rabadan et al.
Nature communications, 13(1), 3340-3340 (2022-06-11)
Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing unprecedented in vitro access to some of the molecular, cellular and developmental mechanisms underlying brain diseases. However, their efficacy in recapitulating brain network properties that encode brain
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