P5390

Prostaglandin B₂

≥98%, synthetic

• Sinonimo/i: (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid, PGB₂
• Formula empirica (notazione di Hill): C₂₀H₃₀O₄
• Numero CAS: 13367-85-6
• Peso molecolare: 334.45
• Beilstein: 2153006
• Numero MDL: MFCD00065730
• Codice UNSPSC: 12352211
• ID PubChem: 24898630
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 100
• Saggio: ≥98%
• Forma fisica: solution
• Solubilità: ethanol: ~100 mg/mL; PBS, pH 7.2: ~2 mg/mL; DMSO: ~50 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCCCC[C@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1
• InChI: 1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1; PRFXRIUZNKLRHM-HKVRTXJWSA-N

Descrizione

Applicazioni

Prostaglandin B2 has been used as an internal standard in high-performance liquid chromatography (HPLC).

Azioni biochim/fisiol

Prostaglandin B2 (PGB2) is an eicosanoid and a lipid mediator. It is synthesized by the dehydration of PGE2. It is a primary prostaglandin associated with the osteoblasts and may induce pulmonary hypertension. PGB2 is also reported to inhibit glucagon stimulated glycogenolysis and forskolin-stimulated adenylate cyclase activity in plasma membranes.

Stato fisico

Prostaglandin B₂ is supplied as a solution in methyl acetate

Nota sulla preparazione

PGB₂ is provided as a solution in methyl acetate. To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. PGB₂, purged with an inert gas, is soluble in ethanol at ~100 mg/mL, DMSO at ~50 mg/mL and in dimethyl formamide at ~ 75 mg/mL.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H319,H336
• Consigli di prudenza: P210 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Rischi supp: EUH066
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 15.8 °F
• Punto d’infiammabilità (°C): -9 °C
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter