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P1494

Sigma-Aldrich

Monoclonal Anti-PMCA4 antibody produced in mouse

~1 mg/mL, clone JA9, purified immunoglobulin, buffered aqueous solution

Sinonimo/i:

Anti-Plasma Membrane Calcium ATPase 4

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About This Item

Numero MDL:
MFCD03097151
Codice UNSPSC:
12352203
NACRES:
NA.44

Origine biologica

mouse

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

JA9, monoclonal

Stato

buffered aqueous solution

Reattività contro le specie

human, rat

Concentrazione

~1 mg/mL

tecniche

immunohistochemistry: suitable
indirect ELISA: 1:15,000 using human or rat tissue
western blot: 1:1,000 using human or rat tissue

Isotipo

IgG1

N° accesso UniProt

P23634

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ATP2B4(493)

Immunogeno

purified human erythrocyte PMCA.

Stato fisico

Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin and 0.05 % sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
SLCL1064
SLCL1516
SLCL0019
SLBN6414
011M1701

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E Carafoli
Basic research in cardiology, 92 Suppl 1, 59-61 (1997-01-01)
The plasma membrane Ca-pump (134 kDa) is stimulated by calmodulin and by other treatments (exposure to acidic phospholipids, treatments with proteases, phosphorylation by protein kinases A or C, self-association to form oligomers). It is the product of four genes (in
T P Stauffer et al.
The Journal of biological chemistry, 270(20), 12184-12190 (1995-05-19)
Antibodies against the four isoforms of the human plasma membrane Ca(2+)-ATPase (PMCA) were raised using an N-terminal sequence of the pump as epitope. The antibodies against PMCA isoforms 1, 2, and 3 were not species-specific, e.g. they also recognized the
Karolina Varga et al.
Cell calcium, 55(2), 78-92 (2014-01-21)
The expression of the plasma membrane Ca2+ ATPase (PMCA) isoforms is altered in several types of cancer cells suggesting that they are involved in cancer progression. In this study we induced differentiation of MCF-7 breast cancer cells by histone deacetylase
Randa Naffa et al.
Cells, 9(5) (2020-05-18)
Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca2+ pump isoform 4b (PMCA4b or ATP2B4) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregulated in cancer
Ling Wang et al.
PloS one, 10(4), e0122932-e0122932 (2015-04-24)
An increased risk for developing essential hypertension, stroke and diabetes is associated with single nucleotide gene polymorphisms in renalase, a newly described secreted flavoprotein with oxidoreductase activity. Gene deletion causes hypertension, and aggravates acute ischemic kidney (AKI) and cardiac injury.

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