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Key Documents

Altri documenti

P0244

Sigma-Aldrich

Anti-PKR (ET-20) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Sinonimo/i:

Anti-Interferon-induced, double-stranded RNA-activated protein kinase (ET-20)

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About This Item

Numero MDL:
MFCD04040533
Codice UNSPSC:
12352203
NACRES:
NA.44

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 68 kDa

Reattività contro le specie

human

tecniche

microarray: suitable
western blot: 1:2,000 using a whole cell extract of the human epitheloid carcinoma HeLa cell line induced with interferon-γ

N° accesso UniProt

P19525

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... EIF2AK2(5610)

Descrizione generale

PKR is a double-stranded RNA-dependent serine/threonine kinase that regulates antiproliferative and antiviral functions of interferons. PKR also functions as a translational inhibitor. In genotoxic environments, PKR mediates CDC2 ubiquitination and G2 arrest in cells . Anti-PKR is antibody is specific for human PKR (68 kDa).

Immunogeno

C-terminus of human PKR (amino acids 531-550), conjugated to KLH

Applicazioni

Anti-PKR (ET-20) antibody I suitable for use in western blot (1:2,000 using a whole cell extract of the human epitheloid carcinoma HeLa cell line induced with interferon-γ) and microarray.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
Yoon, C., H., et al.
EMBO Reports, 393-9, 2010-2010 (2010)
K Kawakubo et al.
Virology, 264(1), 106-114 (1999-11-02)
The double-stranded RNA-dependent protein kinase PKR is an interferon-inducible enzyme that possesses antiviral and antiproliferative activities. We examined expression of PKR transcripts in human placenta tissue and cultured human amnion U cells. Alternative exon 2 structures were identified and characterized
H D Robertson et al.
Biochimie, 78(11-12), 909-914 (1996-01-01)
A model is presented for the regulation of the double-stranded RNA (dsRNA)-activated mammalian protein kinase PKR, which is involved in protein synthesis inhibition and the antiviral response in cells. A series of previous findings abut PKROs behavior are reviewed, including
Z Xu et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 18(8), 609-616 (1998-09-03)
The double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine kinase that plays an important role in the antiviral activities of interferon (IFN). To determine the organization and regulation of the PKR locus, lambda phage and bacterial artificial chromosome (BAC) clones

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