O9512

Oxaliplatin

powder

• Sinonimo/i: [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum
• Formula empirica (notazione di Hill): C₈H₁₄N₂O₄Pt
• Numero CAS: 61825-94-3
• Peso molecolare: 397.29
• Numero MDL: MFCD00866327
• Codice UNSPSC: 12352200
• ID PubChem: 329818942
• NACRES: NA.77

Proprietà

• Forma fisica: powder
• Ideatore: Sanofi Aventis
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N
• InChI: 1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1; ZROHGHOFXNOHSO-BNTLRKBRSA-L

Descrizione

Applicazioni

Oxaliplatin has been used:

• as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay
• for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay
• to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells

Azioni biochim/fisiol

Oxaliplatin a platinum analogue, causes DNA damage and cell death by binding to DNA and forming inter and intrastrand crosslinks preventing replication and transcription. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin is an approved drug for treating colorectal cancer. It is an active ingredient in FOLFOX (Folinic acid:5-FU:oxaliplatin in the ratio 1:10:1 of micromolar concentrations respectively). Oxaliplatin causes both acute and chronic neurotoxicity in patients in a dose dependent manner and is reversible either by reducing or stopping the drug.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox and Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H317,H318,H334,H341,H351,H360FD,H362,H372
• Consigli di prudenza: P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges