C2210000

Cisplatin

European Pharmacopoeia (EP) Reference Standard

• Sinonimo/i: cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Formula condensata: Pt(NH₃)₂Cl₂
• Numero CAS: 15663-27-1
• Peso molecolare: 300.05
• Numero CE: 239-733-8
• Numero MDL: MFCD00011623
• Codice UNSPSC: 41116107
• ID PubChem: 329774978
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: cisplatin
• Produttore/marchio commerciale: EDQM
• Punto di fusione: 270 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Stringa SMILE: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2; LXZZYRPGZAFOLE-UHFFFAOYSA-L

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of the below-given solutions as per European Pharmacopoeia:

• Reference solutions in the identification using infrared absorption spectroscopy and thin-layer chromatography, testing of related substances, and assay using liquid chromatography (General text 2.2.29) of cisplatin, according to the monograph 0599
• Reference solution (b) for the testing of related substances in carboplatin using liquid chromatography (General text 2.2.29), according to the monograph 1081

Azioni biochim/fisiol

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H315,H317,H319,H334,H335,H350
• Consigli di prudenza: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable