O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• Sinonimo/i: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• Formula empirica (notazione di Hill): C₁₂H₁₆ClN₃O₂S · HCl
• Numero CAS: 614-05-1
• Peso molecolare: 338.25
• Numero MDL: MFCD00050656
• Codice UNSPSC: 12352116
• ID PubChem: 24897990
• NACRES: NA.79

Proprietà

• Livello qualitativo: 200
• Saggio: ≥95% (HPLC)
• Stato: powder
• tecniche: HPLC: suitable
• Colore: white to off-white
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H; QHUYPZVMEJLSEB-UHFFFAOYSA-N

Descrizione

Descrizione generale

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

Applicazioni

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
• in the synthesis of oxythiamineH picrolonate salt

Azioni biochim/fisiol

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)