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Key Documents

Altri documenti

O3007

Sigma-Aldrich

Ochratoxin A−BSA conjugate from Aspergillus ochraceus

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About This Item

Numero CAS:
303-47-9
Numero MDL:
MFCD00078079
Codice UNSPSC:
12352200
ID PubChem:
24897972
NACRES:
NA.77

Grado di funzionalizzazione

3-6 mol ochratoxin A per mol BSA

Livello qualitativo

200

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1O[C@H](C)CC2=C(Cl)C=C(C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)C(O)=C21

InChI

1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
RWQKHEORZBHNRI-BMIGLBTASA-N

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Applicazioni

Ochratoxin A−BSA conjugate from Aspergillus ochraceus has been used in carbonate-bicarbonate buffer to coat the high-affinity 96-well polystyrene plates for indirect competitive enzyme-linked immunosorbent assay. It has also been used as a standard in the determination of ochratoxin A in serum by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).

Azioni biochim/fisiol

Ochratoxin A (OTA) is a mycotoxin that is the most toxic among the other ochratoxins. It is produced by Aspergillus carbonarius, A. ochraceus, and Penicillium verrucosum. OTA acts as a major food contaminant and is considered nephrotoxic, teratogenic, neurotoxic, hepatotoxic, and immunotoxic. OTA is known to elevate oxidative stress at a cellular level.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330,H350,H360

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Sigma-Aldrich

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Production of an ochratoxin A antigen with high hapten/carrier molar ratio.
H Worsaae
Acta pathologica et microbiologica Scandinavica. Section C, Immunology, 86C(4), 203-204 (1978-08-01)
Benedikt Cramer et al.
Bioorganic & medicinal chemistry, 18(1), 343-347 (2009-11-19)
The mycotoxin ochratoxin A is a potent inhibitor of the protein biosynthesis and known to be cytotoxic in nanomolar concentrations. In order to investigate the relationship between stereochemistry and cytotoxicity of this compound, all four ochratoxin A stereoisomers have been
Maria-Teresa Gutierrez-Lugo et al.
Bioorganic & medicinal chemistry letters, 21(8), 2480-2483 (2011-03-12)
The cysteinyl transferase mycothiol ligase, or MshC, catalyzes the fourth step in the biosynthesis of the small molecular weight thiol mycothiol. MshC is essential for growth of Mycobacterium tuberculosis. Two groups of known aminoacyl tRNA synthetase inhibitors were evaluated for
Gregory Kaler et al.
The Journal of biological chemistry, 282(33), 23841-23853 (2007-06-08)
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of

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