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Key Documents

M7504

Sigma-Aldrich

Mannan from Saccharomyces cerevisiae

prepared by alkaline extraction

Sinonimo/i:

D-Mannan

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About This Item

Numero CAS:
Numero MDL:
Codice UNSPSC:
12352201
NACRES:
NA.25

Origine biologica

bakers yeast (whole cell)

Livello qualitativo

Forma fisica

powder

Attività ottica

[α]/D 73 to 89 °, c = 1% (w/v) in water

Impurezze

<1.0% Low molecular weight saccharides (TLC)

Colore

beige

Solubilità

water: ~50 g/L

Cationi in tracce

Na: <2%

Temperatura di conservazione

2-8°C

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Descrizione generale

Mannan is the main component of yeast cell wall polysaccharides broadly present in nature, such as in plants, bacteria, yeasts, and other organisms. It comprises a highly branched complex carbohydrate, an α-1,6 backbone with α-1,2- and α-1,3-attached mannose side chains.

Applicazioni

Mannan from Saccharomyces cerevisiae has been used to coat the microtiter wells to quantify the levels of mannose-binding lectin (MBL) using a mannan-binding enzyme-linked immunosorbent assay (ELISA).
Mannan from Saccharomyces cerevisiae has been used in a study to assess nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. It has also been used in a study to investigate new lectins from bulbs of Croccus sativum.

Azioni biochim/fisiol

Mannan exhibits several biological properties, including antiproliferative, antioxidant, and immunomodulatory. It is used as a hardener ingredient and as an emulsion stabilizer. Mannan is also involved in the inhibition of pathogen adherence, regulation of bacterial growth, and enhancement of the immune response.

Nota sulla preparazione

Prepared by method of Haworth.

Altre note

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Four isolectins were isolated from bulbs of Croccus sativum (saffron), using affinity chromatography on mannan-Sepharose 4B, gel filtration and ion-exchange column chromatography in the presence of 8 M urea. The relative molecular masses of these lectins were determined by gel
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Journal of the Chemical Society, 784-791 (1937)
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The uptake of Mycobacterium avium complex (MAC) microorganisms by human peripheral blood monocytes (PBMs) and alveolar macrophages (AMs) is not well understood. We have previously shown, under opsonic conditions, that humoral factors are important in mediating the uptake of MAC
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