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Key Documents

L3625

Sigma-Aldrich

α-Lactose monohydrate

≥99% total lactose basis (GC)

Sinonimo/i:

β-D-Gal-(1→4)-α-D-Glc, 4-O-β-D-Galactopyranosyl-α-D-glucose, Milk sugar

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About This Item

Formula empirica (notazione di Hill):
C12H22O11 · H2O
Numero CAS:
Peso molecolare:
360.31
Numero MDL:
Codice UNSPSC:
12352201
ID PubChem:
NACRES:
NA.25

Origine biologica

bovine milk

Livello qualitativo

Saggio

≥99% total lactose basis (GC)

Forma fisica

powder

Impurezze

≤0.05% Glucose
≤4% β-lactose

Colore

white to off-white

Punto di fusione

219  °C ((426 °F ))

Solubilità

water: 100 mg/mL, clear, colorless

Temperatura di conservazione

room temp

Stringa SMILE

[H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
WSVLPVUVIUVCRA-KPKNDVKVSA-N

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Applicazioni


  • Crystal size, a key character of lactose crystallization affecting microstructure, surface chemistry and reconstitution of milk powder.: This study uses alpha-lactose monohydrate as a standard to investigate how crystal size affects the physical properties of milk powder, which is crucial for optimizing production processes in the dairy industry (Qi X et al., 2024).

  • Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with alpha-Lactose Monohydrate.: Explores the critical role of alpha-lactose monohydrate, as an excipient together with terbutaline sulfate in optimizing particle interactions for enhanced performance of inhalable therapeutics (Ma CY et al., 2023).

  • Terahertz time-domain spectroscopy for the investigation of tablets prepared from roller compacted granules.: This research utilizes alpha-lactose monohydrate to examine the properties of pharmaceutical tablets, offering insights into material characteristics that affect drug delivery systems (Anuschek M et al., 2023).

Azioni biochim/fisiol

Lactose is a dissacharide formed by the condensation of one galactose and one glucose molecule. Lactose is the major sugar in the milk of most species, typically present between 2-8%.
alpha-Lactose is the primary sugar present in milk and the main energy source to a newborn mammalian through its mother′s milk. It is digested by the intestinal lactase (EC 3.2.1.108), an enzyme expressed in newborns. The enzyme′s activity declines following weaning which can lead to lactose intolerance in adult mammals.

Altre note

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Supelco

PHR1025

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Lactose monohydrate powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, NF

SAFC

1.07656

Lactose monohydrate

Gwenola Le Dréan et al.
Nutrients, 11(9) (2019-08-24)
Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota
Johannes Gursch et al.
Journal of pharmaceutical sciences, 104(10), 3481-3489 (2015-07-07)
Over the last years, continuous manufacturing has created significant interest in the pharmaceutical industry. Continuous filtration at low flow rates and high solid loadings poses, however, a significant challenge. A commercially available, continuously operating, dynamic cross-flow filtration device (CFF) is
Sha Liu et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 132-142 (2015-07-30)
Co-administration of an inhaled corticosteroid and long acting beta agonist for chronic obstructive pulmonary disease has reduced mortality compared to either drug alone. This combination reduces exacerbations, hospitalization, emergency department visits and health care costs. A novel fixed-dose combination of

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