K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• Sinonimo/i: 2-(3-Benzoylphenyl)propionic acid
• Formula empirica (notazione di Hill): C₁₆H₁₄O₃
• Numero CAS: 22071-15-4
• Peso molecolare: 254.28
• Numero CE: 244-759-8
• Numero MDL: MFCD00055790
• Codice UNSPSC: 12352200
• ID PubChem: 57654315
• NACRES: NA.77

Proprietà

• product name: Ketoprofen, ≥98% (TLC)
• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Forma fisica: powder
• Solubilità: ethanol: 50 mg/mL, clear, colorless to yellow
• Ideatore: Bayer
• Stringa SMILE: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19); DKYWVDODHFEZIM-UHFFFAOYSA-N
• Informazioni sul gene: human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

Descrizione

Descrizione generale

Ketoprofen belongs to the class of 2-arylpropionic acid.

Applicazioni

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Azioni biochim/fisiol

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Caratteristiche e vantaggi

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H315,H319,H400
• Consigli di prudenza: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges