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N8280

Sigma-Aldrich

Naproxen

meets USP testing specifications

Sinonimo/i:

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid

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About This Item

Formula condensata:
CH3OC10H6CH(CH3)CO2H
Numero CAS:
22204-53-1
Peso molecolare:
230.26
Beilstein:
3591068
Numero CE:
244-838-7
Numero MDL:
MFCD00010500
Codice UNSPSC:
12352200
ID PubChem:
24897861
NACRES:
NA.21

agenzia

USP/NF
meets USP testing specifications

Livello qualitativo

200

Forma fisica

powder

Punto di fusione

152-154 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI

1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
CMWTZPSULFXXJA-VIFPVBQESA-N

Informazioni sul gene

human ... MAPK14(1432) , PTGS1(5742) , PTGS2(5743)
rat ... Alox5(25290) , Ptgs1(24693)

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Azioni biochim/fisiol

Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335,H361fd,H411

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number
SLCH8076
SLCF6198
SLBV6889
SLBV2253
SLBP7866V

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2-(6-Methoxy-2-naphthyl)propanoic acid AldrichCPR

Sigma-Aldrich

CDS000407

2-(6-Methoxy-2-naphthyl)propanoic acid

(R)-(−)-6-Methoxy-α-methyl-2-naphthaleneacetic acid 98%

Sigma-Aldrich

570842

(R)-(−)-6-Methoxy-α-methyl-2-naphthaleneacetic acid

Ibuprofene ≥98% (GC)

Sigma-Aldrich

I4883

Ibuprofene

Ibuprofene meets USP testing specifications

Sigma-Aldrich

I7905

Ibuprofene

Naproxen sodium United States Pharmacopeia (USP) Reference Standard

USP

1457403

Naproxen sodium

Flurbiprofen cyclooxygenase inhibitor

Sigma-Aldrich

F8514

Flurbiprofen

Naproxen solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

N-042

Naproxen solution

Ketoprofen meets USP testing specifications

Sigma-Aldrich

K2012

Ketoprofen

J Rossat et al.
Clinical pharmacology and therapeutics, 66(1), 76-84 (1999-08-03)
To compare the renal hemodynamic and tubular effects of celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2) to those of naproxen, a nonselective inhibitor of cyclooxygenases in salt-depleted subjects. Forty subjects were randomized into four parallel groups to receive 200 mg
Jiayang Li et al.
Journal of the American Chemical Society, 135(2), 542-545 (2012-11-10)
As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti-inflammatory drugs (NSAIDs) also associate with the adverse gastrointestinal and renal effects and cardiovascular risks. Thus, it is beneficial to develop topical gels that selectively inhibit cyclooxygenase-2
Michela Campolo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4489-4499 (2013-08-01)
Spinal cord trauma causes loss of motor function that is in part due to the ensuing inflammatory response. Hydrogen sulfide (H2S) is a potent, endogenous anti-inflammatory and neuroprotective substance that has been explored for use in the design of novel
Dong Qing Zhang et al.
Chemosphere, 91(1), 14-21 (2012-12-27)
Scirpus validus was grown hydroponically and exposed to the pharmaceuticals, carbamazepine and naproxen at concentrations of 0.5-2.0 mg L(-1) for an exposure duration of up to 21 d. By the end of experiment, carbamazepine elimination from the nutrient solution reached
D Haupt et al.
Journal of biochemical and biophysical methods, 25(4), 273-284 (1992-12-01)
A column-switching system for fast determination of (R)- and (S)-naproxen in liver microsomes has been developed. The centrifuged sample was injected directly onto a pre-column with octadecylcoated silica. The retained analytes were then directed to an alpha 1-AGP column using
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Chromatograms

application for HPLC

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