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I9659

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in mouse

Name: Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in mouse
Brand: SIGMA

clone 75014, purified immunoglobulin, lyophilized powder

Sinonimo/i:

Anti-IGF2, Anti-INSIGF

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About This Item

Numero MDL:

MFCD00162567

Codice UNSPSC:

51111800

NACRES:

NA.41

Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

75014, monoclonal

Forma fisica

lyophilized powder

Reattività contro le specie

human

tecniche

western blot: 1-2 μg/mL

Isotipo

IgG2a

N° accesso UniProt

P01344

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IGF2(3481)

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Immunogeno

purified, E. coli-derived recombinant human insulin-like growth factor-II.

Azioni biochim/fisiol

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Prodotti correlati

N° Catalogo

Descrizione

Determinazione del prezzo

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.

Robert G Maki

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(33), 4985-4995 (2010-10-27)

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the

IGF2: epigenetic regulation and role in development and disease.

Wendy Chao et al.

Cytokine & growth factor reviews, 19(2), 111-120 (2008-03-01)

Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted--only one allele is active, depending on parental origin--and this pattern of expression is maintained epigenetically in almost all

Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications.

C J Rosen

Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)

The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated

Insulin-like growth factor system and sporadic malignant melanoma.

Ettore Capoluongo

The American journal of pathology, 178(1), 26-31 (2011-01-13)

Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

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