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I9534

Sigma-Aldrich

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat

clone 122404, purified immunoglobulin, lyophilized powder

Sinonimo/i:

Anti-Igf-II, Anti-Igf2, Anti-Mpr, Anti-Peg2

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About This Item

Codice UNSPSC:
51111800
NACRES:
NA.41

Origine biologica

rat

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

122404, monoclonal

Forma fisica

lyophilized powder

Reattività contro le specie

mouse

tecniche

capture ELISA: 2-8 μg/mL
western blot: 1-2 μg/mL

Isotipo

IgG2a

N° accesso UniProt

P09535

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Igf2(16002)

Immunogeno

purified, E. coli-derived recombinant mouse insulin-like growth factor-II.

Azioni biochim/fisiol

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Robert G Maki
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(33), 4985-4995 (2010-10-27)
Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the
Wendy Chao et al.
Cytokine & growth factor reviews, 19(2), 111-120 (2008-03-01)
Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted--only one allele is active, depending on parental origin--and this pattern of expression is maintained epigenetically in almost all
C J Rosen
Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)
The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated
Ettore Capoluongo
The American journal of pathology, 178(1), 26-31 (2011-01-13)
Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

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