I7908

IL-2 human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture

• Sinonimo/i: IL-2, Interleukin-2, T-cell growth factor
• Numero MDL: MFCD00165721
• Codice UNSPSC: 12352202
• NACRES: NA.75

Proprietà

• Nome del prodotto: Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture
• Origine biologica: human
• Livello qualitativo: 200
• Ricombinante: expressed in Pichia pastoris
• Saggio: ≥98% (SDS-PAGE and HPLC)
• Stato: lyophilized powder
• PM: predicted mol wt ~15 kDa
• Confezionamento: pkg of 10KU
• tecniche: cell culture | mammalian: suitable
• Impurezze: endotoxin, tested
• N° accesso UniProt: P60568
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... IL2(3558)

Descrizione

Applicazioni

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Azioni biochim/fisiol

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Risultati analitici

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)