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Documenti fondamentali

I4269

Sigma-Aldrich

IL-4 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

IL-4, Interleukin-4 human, hIL-4

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About This Item

Numero MDL:
MFCD00151705
Codice UNSPSC:
12352202
NACRES:
NA.77

Nome del prodotto

Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in E. coli

Saggio

≥98% (SDS-PAGE)

Stato

lyophilized powder

Potenza

≤0.400 ng/mL EC50

Qualità

endotoxin tested

PM

14.9 kDa (containing 129 amino acid residues)

Confezionamento

pkg of 5 and 50 μg

tecniche

cell culture | mammalian: suitable

Impurezze

≤1.000 EU/μg

Colore

white

N° accesso UniProt

P05112

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IL4(3565)
mouse ... IL4(3565)

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Categorie correlate

Descrizione generale

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including differentiation of naive T cells into the TH2 phenotype, promoting B cell proliferation, antibody isotype switching, and expression of other TH2 cytokines including IL-5 and IL-9.1,2 IL-4 plays a critical role in the development of allergic inflammation and asthma.3

IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.4

Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.5

Applicazioni

Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis.

Stato fisico

Lyophilized from a sterile filtered solution.

Risultati analitici

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
069M4063V
069M4064V
118M4071V
118M4070V
078M4155V

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IL-13 human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP3274

IL-13 human

IL-13 Variant human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3076

IL-13 Variant human

Interleukin-4 from rat recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

Sigma-Aldrich

I3650

Interleukin-4 from rat

T Yokota et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(16), 5894-5898 (1986-08-01)
A cDNA sequence coding for a human interleukin has been isolated from a concanavalin A-activated human T-cell cDNA library based on homology with a mouse interleukin cDNA that expresses B-cell stimulatory factor 1 (BSF-1) activity and T-cell- and mast-cell-stimulating activities.
Zhu Wang et al.
Bioengineered, 13(3), 7683-7696 (2022-03-17)
Diabetic nephropathy (DN) is a common complication of diabetes mellitus which can result in renal failure and severely affect public health. Several studies have revealed the important role of podocyte injury in DN progression. Although, the involvement of exosomes derived
Yen-Kuang Lin et al.
Oxidative medicine and cellular longevity, 2022, 9964689-9964689 (2022-02-01)
Apolipoprotein (a)/lipoprotein(a) (Lp(a)), a major carrier of oxidized phospholipids, and α7-nicotinic acetylcholine receptor (α7-nAChR) may play an important role in the development of coronary artery spasm (CAS). In CAS, the association between Lp(a) and the α7-nAChR-modulated inflammatory macrophage polarization and
Masanori Kobayashi et al.
Cancer immunology, immunotherapy : CII, 63(8), 797-806 (2014-04-30)
Dendritic cell (DC)-based cancer vaccines may have a significant benefit to patients with advanced pancreatic cancer. However, variations among clinical studies make it difficult to compare clinical outcomes. Here, we identified factors that determined the clinical benefits by analyzing data
Michelle A Favila et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5863-5872 (2014-05-09)
Leishmania major-infected human dendritic cells (DCs) exhibit a marked induction of IL-12, ultimately promoting a robust Th1-mediated response associated with parasite killing and protective immunity. The host cell transcription machinery associated with the specific IL-12 induction observed during L. major
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Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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