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I1020

Sigma-Aldrich

IL-4 mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

mIL-4, Interleukin-4 human

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About This Item

Numero MDL:
MFCD00166698
Codice UNSPSC:
12352202
NACRES:
NA.77

product name

Interleukin-4 from mouse, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Origine biologica

mouse

Ricombinante

expressed in E. coli

Saggio

≥98% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

0.1-2.0 ng/mL ED50/EC50

Qualità

endotoxin tested

PM

~13.5 kDa

Confezionamento

pkg of 5 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<0.1 EU/μg

N° accesso UniProt

P07750

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... Il4(16189)

Applicazioni

Interleukin-4 from mouse has been used:
  • as a component of cell culture media for class switch recombination assay
  • to study its therapeutic benefits for mucosal healing
  • as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)

Azioni biochim/fisiol

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

Stato fisico

Lyophilized, 0.2 μm filtered, with no additives.

Risultati analitici

The proliferative activity is tested in culture using mouse HT-2 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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R Fernandez-Botran et al.
The Journal of experimental medicine, 164(2), 580-593 (1986-08-01)
T cell-derived supernatants (SN) that contain B cell-stimulatory factor 1 (BSF-1) and lack IL-2 promote the growth of the IL-2-dependent T cell line, HT-2, as well as three other clones or lines of T cells that can provide help to
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Muscle damage induces massive macrophage infiltration of the injury site, in which activated pro-inflammatory and anti-inflammatory phenotypes (currently classified as M1 and M2, respectively) have been documented as distinct functional populations predominant at different times after the conventional acute injury
New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice
Silva JC, et al.
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Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells
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VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells
Khan AJ, et al.
Oncotarget, 9(40), 25833-25833 (2018)
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