I2276

Interleukin-12 human

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

• Sinonimo/i: IL-12
• Numero MDL: MFCD00212975
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Livello qualitativo: 200
• Ricombinante: expressed in baculovirus infected Sf21 cells
• Saggio: ≥97% (SDS-PAGE and N-terminal analysis)
• Forma fisica: lyophilized powder
• Potenza: 0.01-0.05 ng/mL ED₅₀
• PM: glycoprotein 75 kDa
• Confezionamento: pkg of 5 μg
• tecniche: cell culture | mammalian: suitable
• Impurezze: endotoxin, tested
• N° accesso UniProt: P29459,; P29460
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... IL12A(3592) , IL12B(3593)

Descrizione

Azioni biochim/fisiol

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)