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H9633

Sigma-Aldrich

L-Homocysteic acid

≥98% (TLC)

Sinonimo/i:

L-2-Amino-4-sulfobutyric acid

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About This Item

Formula empirica (notazione di Hill):
C4H9NO5S
Numero CAS:
14857-77-3
Peso molecolare:
183.18
Numero MDL:
MFCD00066018
Codice UNSPSC:
12352106
ID PubChem:
24895863
NACRES:
NA.32

product name

L-Homocysteic acid, ≥95%

Saggio

≥95%
≥98% (TLC)

Forma fisica

powder

Colore

white to off-white

applicazioni

cell analysis

Stringa SMILE

N[C@@H](CCS(O)(=O)=O)C(O)=O

InChI

1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
VBOQYPQEPHKASR-VKHMYHEASA-N

Applicazioni

L-Homocysteic acid has been used to study hydrogen peroxide-mediated changes in physiological and pathological conditions in the nervous system.

Azioni biochim/fisiol

L-Homocysteic acid (L-HCA) is an endogenous neurotransmitter ligand of NMDA (N-methyl-D-aspartate) receptors. It is an analog of glutamate and competitively suppresses glutamate-cystine (xc-) antiporter function in neurons, causing decrease in cysteine uptake.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Seleno-DL-cystine powder

Sigma-Aldrich

S1650

Seleno-DL-cystine

Selenomethionine United States Pharmacopeia (USP) Reference Standard

USP

1611955

Selenomethionine

3-Amino-1-propanesulfonic acid 97%

Sigma-Aldrich

A76109

3-Amino-1-propanesulfonic acid

DL-Homocysteine thiolactone hydrochloride ≥99.0% (AT)

Sigma-Aldrich

53530

DL-Homocysteine thiolactone hydrochloride

Seleno-L-cystine 95%

Sigma-Aldrich

545996

Seleno-L-cystine

Emina from bovine, ≥90%

Sigma-Aldrich

H9039

Emina

S-(5′-Adenosyl)-L-homocysteine crystalline

Sigma-Aldrich

A9384

S-(5′-Adenosyl)-L-homocysteine

L-cisteina ≥97%, FG

Sigma-Aldrich

W326305

L-cisteina

M Piraud et al.
Rapid communications in mass spectrometry : RCM, 19(22), 3287-3297 (2005-10-20)
Seventy-six compounds of biological interest for the diagnosis of inherited disorders of amino acids (AA) metabolism have previously been demonstrated to be detectable in positive mode electrospray ionisation tandem mass spectrometry (ESI-MS/MS), after separation by ion-pairing reversed-phase liquid chromatography (RPLC).
Hari H Subramanian et al.
The Journal of comparative neurology, 526(2), 229-242 (2017-09-07)
The nucleus retroambiguus (NRA) is a neuronal cell group in the medullary ventrolateral tegmentum, rostrocaudally between the obex and the first cervical spinal segment. NRA neurons are premotor interneurons with direct projections to the motoneurons of soft palate, pharynx, and
Itopa E Ajayi et al.
Respiratory physiology & neurobiology, 252-253, 18-27 (2018-03-20)
Changes in cardiorespiratory control accompany the expression of complex emotions, indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have focussed on the role of the prefrontal cortex in autonomic regulation. However, the role of the hippocampus, also
J W Olney et al.
Brain research bulletin, 19(5), 597-602 (1987-11-01)
L-Homocysteic acid (L-HCA) has been proposed as a natural transmitter at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor based on recent evidence that L-HCA occurs L-HCA occurs naturally in the mammalian CNS, is released from K+ stimulated brain
T Knöpfel et al.
Neuroscience letters, 81(1-2), 188-192 (1987-10-16)
The effects of ionophoretically applied L-homocysteate (L-HCA), L-glutamate (L-Glu) and N-methyl-D-aspartate (NMDA) were compared in rat neocortical neurons recorded intracellularly in vitro. The firing pattern and the time course of membrane depolarization induced by L-HCA resembled those of NMDA responses.
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