H7660
Heregulin-β1 (EGF Domain) human
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Sinonimo/i:
HRG-β1
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About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
≥98% (SDS-PAGE)
Stato
lyophilized powder
Potenza
<0.50 ng/mL
PM
predicted mol wt 8 kDa
Confezionamento
pkg of 10 and 50 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
Impurezze
endotoxin, tested
Colore
white
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... NRG1(3084)
Azioni biochim/fisiol
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
Risultati analitici
The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
Wei Tan et al.
The Journal of biological chemistry, 282(33), 24343-24351 (2007-06-15)
Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. Recently, altered expression of a novel isoform (type IV) in the brain has
Paul J Harrison et al.
Biological psychiatry, 60(2), 132-140 (2006-01-31)
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of
A M Addington et al.
Molecular psychiatry, 12(2), 195-205 (2006-10-13)
Childhood-onset schizophrenia (COS), defined as onset of psychosis by the age of 12, is a rare and malignant form of the illness, which may have more salient genetic influence. Since the initial report of association between neuregulin 1 (NRG1) and
Shuji Wakatsuki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 19(1), 66-77 (2013-11-22)
After peripheral nerve injury, Schwann cells gain a migratory phenotype and remodel their extracellular matrix to provide a supportive environment for axonal regeneration. The soluble neuregulin-1 isoform, that is, glial growth factor (GGF), is expressed in regenerating axons of injured
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