H7017
Hemocyanin from Megathura crenulata (keyhole limpet)
Sinonimo/i:
KLH, Keyhole limpet hemocyanin
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About This Item
Prodotti consigliati
Origine biologica
Megathura crenulata
Livello qualitativo
Stato
powder
Confezionamento
vial of KLH (KLH is present by weight at approximately 1 part KLH to 5 parts total solid.)
tecniche
ELISA: suitable
Solubilità
H2O: soluble
Temperatura di conservazione
2-8°C
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Descrizione generale
Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.
Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.
Applicazioni
Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response. Hemocyanins stimulate Th1 reactions without known side effects, which make them ideal for long-term continuous treatment of cancer.
Stato fisico
Lyophilized with stabilizing buffer
Ricostituzione
Reconstitute with deionized water to a KLH concentration of 10 mg/mL, to yield an opalescent solution in 31 mM sodium phosphate buffer, pH 7.4, containing 0.46 M NaCl, 2% PVP and 41 mM sucrose.
Reconstituted protein solution may be stored up to 2 months at −20 °C.
Reconstituted protein solution may be stored up to 2 months at −20 °C.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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