H5916

Human Growth Hormone

HumanKine^®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

• Sinonimo/i: HGH
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• product name: Human Growth Hormone human, HGH, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• Origine biologica: human
• Livello qualitativo: 100
• Ricombinante: expressed in HEK 293 cells
• Saggio: ≥95% (SDS-PAGE)
• Forma fisica: lyophilized powder
• Potenza: ≤0.5 ng/mL EC₅₀
• PM: monomer 22 kDa (non-glycosylated)
• Confezionamento: pkg of 10 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• tecniche: cell culture | mammalian: suitable
• Impurezze: ≤1 EU/mg
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Human growth hormone (HGH), also called somatotropin, is a peptide hormone that consists of a long single chain of amino acids. It is naturally secreted by somatotropic cells in the anterior pituitary gland of the human body.

Applicazioni

Human Growth Hormone human has been used as a supplement in culture media to study its effect on the immune response in fish cell lines. It has also been used as a supplement in biliary differentiation medium (BDM) for differentiation of human embryonic stem cells (hESCs)/ human induced pluripotent stem cells (hiPSCs)-derived hepatoblasts.

Azioni biochim/fisiol

Human growth hormone (HGH) is required for normal human growth and development. HGH modifies a variety of physiological functions by stimulating the expression of insulin-like growth factor I and increases calcium retention and bone density. HGH increases muscle mass, promotes lipolysis, and reduces liver uptake of glucose. Abnormalities in the regulation of HGH lead to various growth disorders such as gigantism or acromegaly due to hypersecretion of HGH. Conversely, HGH deficiency leads to growth deficit in children and GH deficiency syndrome in adults.

Stato fisico

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota sulla preparazione

HumanKine, Human Growth Hormone (HGH) is expressed as a non-glycosylated monomer in human HEK 293 cells and has an apparent molecular mass of 22 kDa.

Risultati analitici

The activity was determined by the dose-dependent stimulation of the proliferation of rat lymphoma line Nb2-11 cells (prolactin indicator cell line).

Note legali

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable