S9129

Somatostatin

≥97% (HPLC), powder

• Sinonimo/i: Growth hormone release inhibiting factor, SRIF, Somatostatin-14, Somatotropin release inhibiting factor
• Formula empirica (notazione di Hill): C₇₆H₁₀₄N₁₈O₁₉S₂
• Numero CAS: 38916-34-6
• Peso molecolare: 1637.88
• Beilstein: 6436064
• Numero CE: 254-186-5
• Numero MDL: MFCD00076762
• Codice UNSPSC: 12352200
• ID PubChem: 24899825
• NACRES: NA.32

Proprietà

• Livello qualitativo: 200
• Saggio: ≥97% (HPLC)
• Stato: powder
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O
• InChI: 1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57?,58-,59-,62-,63-/m0/s1; NHXLMOGPVYXJNR-FQSIDJEASA-N
• Informazioni sul gene: human ... SSTR1(6751) , SSTR2(6752) , SSTR3(6753) , SSTR4(6754) , SSTR5(6755)

Descrizione

Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Descrizione generale

Somatostatin (SST) is a peptide.

Somatostatin is expressed in endocrine cells and nerve fibers of the gastrointestinal tract. It is also expressed in other tissues.

Applicazioni

Somatostatin has been used:

• as a standard antigen to detect antibodies in an indirect enzyme-linked immunosorbent assay (ELISA) method
• to study the effect of somatostatin on oxytocin release during pregnancy in rats
• to test the specificity of the avidin-biotinylated horseradish peroxidase immunocytochemical procedure to visualize somatostatin-immunoreactive (SS-IR) neurons

Azioni biochim/fisiol

Somatostatin (SST) performs several functions like anti-proliferation, pro-apoptosis and anti-migration. Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3-5).

Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.

Altre note

Lyophilized from 0.1% TFA in H2O

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)