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H0135

Sigma-Aldrich

Hydrocortisone

γ-irradiated, powder, BioXtra, suitable for cell culture

Sinonimo/i:

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Formula empirica (notazione di Hill):
C21H30O5
Numero CAS:
Peso molecolare:
362.46
Beilstein:
1354819
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.77

Origine biologica

synthetic (organic)

Livello qualitativo

Sterilità

γ-irradiated

Nome Commerciale

BioXtra

Saggio

≥80% (HPLC)

Forma fisica

powder

tecniche

cell culture | mammalian: suitable

Punto di fusione

211-214 °C (lit.)

Solubilità

ethanol: 1 mg/mL, clear

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
JYGXADMDTFJGBT-VWUMJDOOSA-N

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Descrizione generale

Hydrocortisone for use in epithelial and endothelial adherent cell culture applications.

Applicazioni

Hydrocortisone is used for the following applications:
  • Used in myogenic induction and identification
  • Used in long-term stromal cultures and methylcellulose cultures (one of the components in the culture medium)
  • Used in adipogenic differentiation (one of the components in adipogenic medium)
  • Used in cell culture: The human mammary epithelial cell MCF-10A cells were maintained in DMEM/F12 and supplemented with hydrocortisone along with other components
  • The SUM149 cell line was established from a primary IBC and grown in FBS supplemented with Ham′s F12 medium containing insulin and hydrocortisone
  • Used in differentiation assays of melanoma spheroid cells

Azioni biochim/fisiol

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Stato fisico

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Ricostituzione

To prepare 50 μg/mL stock solution; add 1 mL absolute ethanol, gently swirl to dissolve, add 19 mL sterile medium while mixing.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Health hazard

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Repr. 1A - STOT RE 2

Organi bersaglio

Adrenal gland,Bone marrow

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


Certificati d'analisi (COA)

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